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The importance of amino acids, concerning muscle protein
synthesis, has long been accepted and validated; however, which exact
amino acids at what specific ratios are the more important questions,
along with what total dosage amount and when should it be consumed. We
utilized a meta analysis on over 10 years of ergogenic amino acid
research to bring you the most comprehensively anabolic amino acid
composition available. It even outperforms whole protein.
Amino Acids (EAAs) have consistently outperformed whole protein and
other mixed amino acid formulas regarding stimulating Muscle Protein
Synthesis (MPS) and maintaining a positive net protein balance (NPB).
Succinctly, AminOD utilizes 7 of the 10 EAAs, based upon the 6g
composition derived from Tipton, Borsheim, et al. data and strategically
merged with the ratios from Pasiakos studies using heightened L-Leucine
content. It is devoid of L-Methionine due to life extension purposes
discussed in detail below.
Whole protein, consumed either pre or post
exercise, was proven inferior at enhancing muscle amino acid uptake and
muscle protein balance when compared to EAA + Carbohydrate (CHO)
solution taken at either of the same time-points (Tipton 2007).
Consuming this 6g mixture 1 and 2 hours post, without CHO, was also
shown to be 2x more impactful on stimulating net muscle protein balance
when compared to another 6g blend of EAAs and Non Essential Amino Acids
(NEAAs), much like whole protein (Borsheim 2002). This study was
powerful as it proved there is no need for NEAAs regarding muscle
protein synthesis (MPS), only EAAs. It also let us know we could drop
the 35 CHO, as it proved they had no added benefit on MPS. Furthermore,
EAAs, not NEAAs, were shown to individually stimulate MPS when
administered in bolus dosages (Smith et all 1994), further sustaining
that NEAAs are irrelevant.
The research speaks, a carefully designed EAA formula is more anabolic than whole protein...and a ton cheaper!
6g EAA composition, used by multiple researchers as depicted above,
served as our base structural formula for AminOD, as it was designed
specifically to mimic muscle tissue amino acid content (Borsheim, et al.
2002) and had consistent human, oral research surrounding it. We chose
to enhance the Leucine content based on Dreyers work showing Leucine
enriched EAA + CHO formula, consumed post resistance training, increased
mTOR activation leading to greater MPS (Dreyer et al. 2008). We used
another, more current, EAA composition to determine AminODs amino acid
ratios, with the goal of enriching the L-Leucine content within our
dosage. This particular 10g EAA composition with 35% Leucine elicited a
33% greater MPS response compared to another 10g identical composition
with 18.6% Leucine. The other EAAs within our composition are reduced
parallel to this studys ratios, to allow 35% Leucine enrichment
inquiring minds, aromatic amino acids L-Tryptophan and L-Tyrosine do
not appear within our formula, despite being essential amino acids.
Researchers did not include these within their EAA spectrums possibly
due to interference with anabolic branch chain amino acid (BCAA)
absorption, as they compete for the same receptor, LAT1 (Large Neutral
Amino Acid Transporter). The enhanced BCAA:Tryptophan ratio allows for
increased BCAA transport and reduced fatigue. Additionally, Tryptophan
is a precursor to Melatonin which promotes sleep; most users would find
drowsiness as an unwelcome effect as this product will be consumed
around training and/or throughout the day.
L-Methionine has also been
omitted, by us, due to many life extension researchers strong
contention of a direct link between heightened L-Methionine consumption
and shortened lifespan (Trepanowski 2011). L-Methionine increases
homocysteine, which leads to cardiovascular disease and increased
mortality rate. Also, it is the most vulnerable amino acid to oxidation
by reactive oxygen species and causes mitachondrial DNA damage. Also, as
mentioned earlier, Smiths work assures us individual EAAs alone spur
MPS, further solidifying our decision.
Also of note, BCAAs have been
shown to be anabolic on their own, especially mTOR stimulating
L-Leucine, as well as fatigue delaying (Blomstrand 2006). BCAAs compete
for the same receptor as Aromatic Amino Acids (AAAs)(tyrosine,
tryptophan, and phenylalanine), therefore, consuming bolus amounts of
BCAAs would increase your chances for their absorption over the AAAs.
Increasing the blood BCAA pool would lessen the the amount of
L-Tryptophan the brain can take up, thereby reducing melatonin
production and reducing fatigue.
Theres no wrong time to
take AminOD. Based on the findings outlined below, we recommend
consuming multiple servings per day, inside and outside of your workout
window. Tipton, et. al. showed that our base 6g EAA composition + 35g
CHO, consumed pre workout, stimulated amino acid delivery and uptake,
hence MPS, greater than when the solution was consumed postworkout
(Tipton 2001). The same 6g EAA composition was 2x more impactful at
stimulating net protein balance compared to a mixed NEAA solution (3g
EAA+3gNEAA) when consumed at 60 and 120 minutes post resistance exercise
(Borsheim 2002). EAA + CHO consumed 60 minutes post resistance training
was shown to increase mTOR signaling and MPS (Dreyer 2008). More
recently, Pasiakos showed a 10g Leucine-enriched EAA solution, consumed
intra workout, elicited increased MPS.
The above research provides
evidence for effectively taking a serving of AminOD PRE workout, INTRA
workout, and/or again at 1 and 2 hours POST resistance exercise.
Maximize muscle protein synthesis by consuming a serving of AminOD pre
workout as well as at 1 and 2 hours post workout.
using AminOD as a muscle protein synthesis enhancing, recovery
accelerating workout adjunct or simply as an amino-acid-rich flavor
burst to your daily water intake, AminOD is the anytime anabolic. Used
PRE, INTRA, POST, or a combination thereof, ensure maximal protein
synthesis and muscle recovery by bathing your muscles in AminOD. It is
more anabolic than whole protein AND substantially cheaper. Welcome to
the next generation, enthusiastically provided to you by Purus Labs.